Cardiovascular and Interventional Radiological Society of Europe
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ResearchCIEMAR

CIRSE Registry for Emprint Microwave Ablation

Status: in design

With CIEMAR the society plans to close the existing gap in real-life evidence regarding percutaneous microwave ablation for the treatment of liver metastases.
CIEMAR will be a large-scale data collection on microwave ablation in Europe that will have the chance to further the treatment's position in guidelines.

Study summary

CIEMAR is a European-wide, prospective, observational (non-interventional) study that will gather data on microwave ablation of colorectal liver metastases using the EMPRINT microwave ablation device. Microwave tumour ablation provides a minimally invasive, potentially curative treatment option for various neoplasms and has been in use for over 15 years. The safety and efficacy of CRLM ablation has been demonstrated in randomised trials but large and prospective real-life data on effectiveness of microwave ablation is still lacking.

Data will be collected prospectively from medical centres throughout Europe via an electronic data capture (EDC) system. The primary objective is the observation of the clinical practice of microwave ablation of liver metastases from colorectal carcinoma to demonstrate efficacy in a large, multi-national cohort with special emphasis on local tumour control in the liver.

The CIRSE Emprint Microwave Ablation Registry is funded by a grant provided by Medtronic.

Endpoints

Primary endpoint

  • Local tumour control 12 months after treatment on a per lesion basis

Secondary endpoints

  • Adverse events and toxicity
  • Overall survival
  • Overall disease-free survival
  • Hepatic disease-free survival
  • Time to untreatable progression by thermal ablation
  • Systemic cancer therapy vacation
  • Quality of life
  • Economic aspects

Steering Committee

NameHospital
Phillipe L. Pereira (Co-Chairperson)SLK Kliniken Heilbronn/DE
Thierry de Baère (Co-Chairperson)Institute Goustave Roussy/FR
Reto BaleUniversitätsklinik Innsbruck/AT
Alice GillamsThe London Clinic/UK
Nahum GoldbergHadassah Medical Center/IL
Thomas HelmbergerStädtisches Klinikum München/DE
Martijn MeijerinkVU Meidisch Centrum/NL
Franco OrsiEuropean Institute of Oncology Milan/IT
Theo RuersCancer Institute of Amsterdam/NL
Thomas VoglUniversitätsklinik Frankfurt/DE

Documents

Project summary